发明名称 |
CHEMICAL CROSSLINKERS |
摘要 |
Disclosed herein are methods of chemical conjugation comprising contacting a lysosomal enzyme with a first crosslinking agent to introduce aldehyde groups; contacting a lysosomal targeting peptide with a second crosslinking agent to introduce a hydrazide group at the N- terminal residue; contacting the lysosomal enzyme with aldehyde groups of step a. with the lysosomal targeting peptide with a hydrazide group at the N-terminal residue of step b; and forming a lysosomal enzyme-lysosomal targeting peptide conjugate. |
申请公布号 |
WO2014143701(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
WO2014US27771 |
申请日期 |
2014.03.14 |
申请人 |
AMICUS THERAPEUTICS, INC. |
发明人 |
DO, HUNG |
分类号 |
A61K38/30;C07K14/65;C12N9/00 |
主分类号 |
A61K38/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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