发明名称 |
CEFTOLOZANE PHARMACEUTICAL COMPOSITIONS |
摘要 |
Pharmaceutical compositions can include an amount of sodium chloride effective to stabilize ceftolozane in an antibiotic formulation. |
申请公布号 |
US2014275000(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
US201414212590 |
申请日期 |
2014.03.14 |
申请人 |
Cubist Pharmaceuticals, Inc. |
发明人 |
Damour Nicole Miller;Terracciano Joseph |
分类号 |
A61K31/546;A61K47/02 |
主分类号 |
A61K31/546 |
代理机构 |
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代理人 |
|
主权项 |
1. A pharmaceutical composition comprising 125 mg to 500 mg sodium chloride per 1,000 mg of ceftolozane active, wherein the decrease in ceftolozane total purity is not greater than about 4% after storing the pharmaceutical composition for seven days in a sealed container at 60° C., as determined by HPLC using a Develosil column ODS-UG-5; 5 micrometers; 250×4.6 mm, a mobile phase of sodium perchlorate buffer solution (pH 2.5)/CH3CN 90:10 (v/v) at a 1.0 mL/min flow rate and oven temperature of 45° C. |
地址 |
Lexington MA US |