发明名称 COMPOSITION OF A SUSTAINED-RELEASE DELIVERY AND METHOD OF STABILIZING PROTEINS DURING FABRICATION PROCESS
摘要 As described herein, controlled and sustained administration of a therapeutic agent, such as a protein through the administration of one or more microparticles, may improve treatment of conditions, such as undesirable ocular conditions. The microspheres can be formulated to provide a sustained release of a protein, while reducing the number of protein aggregates, achieving desirable release profiles, and increasing stability of the protein within the microsphere formulations.
申请公布号 US2014274873(A1) 申请公布日期 2014.09.18
申请号 US201414209683 申请日期 2014.03.13
申请人 ALLERGAN, INC. 发明人 Tran Simon H.;Wu Cindy
分类号 A61K47/34;A61K38/16 主分类号 A61K47/34
代理机构 代理人
主权项 1. A composition of matter comprising: particles, the particles comprising a protein, a biodegradable polymer, and one or more excipients; wherein the particles are configured to deliver the protein for a period of time of not less than two months.
地址 Irvine CA US