POROUS COMPOSITES WITH HIGH-ASPECT RATIO CRYSTALS

摘要

The present disclosure is directed toward composite materials comprising high aspect ratio habits of drug crystals which can be partially or fully extending into a substrate, and additionally, can be projecting from a substrate at an angle of about 20° to about 90°. The present disclosure is directed toward medical devices, such as medical balloons, comprising said composite and methods of using and making the same. The described composite can be used for the local treatment of vascular disease. The present disclosure is also directed toward paclitaxel crystals with a hollow acicular habit.

主权项

1. A composite comprising a plurality of high aspect ratio paclitaxel crystals projecting from a porous substrate at an angle of at least 20 to 90 degrees relative to the substrate and extending at least partially into said porous substrate.