发明名称 |
HETEROCYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DISEASE |
摘要 |
Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions, including but not limited to diseases involving fibrosis, such as fibrosis of the heart, kidney, liver and lung, and scleroderma; inflammatory diseases such as diabetic nephropathy and inflammatory bowel disease; ocular diseases such as dieases involving retinal degeneration; nerve diseases such as pruritus and pain. Non- limiting examples of those compounds include (RS)-3-Cyclopropyl-2-{4-[3-methyl-4-((R)- 1 -phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-benzyloxy}-propionic acid and (R)-1 -(4'- {5-[1 -(2-Chloro-phenyl)-ethoxycarbonylamino]-4-fluoro-pyrazol-1 -yl}-2-fluoro-biphenyl-4- yl)-cyclopropanecarboxylic acid. |
申请公布号 |
WO2014145873(A2) |
申请公布日期 |
2014.09.18 |
申请号 |
WO2014US30712 |
申请日期 |
2014.03.17 |
申请人 |
EPIGEN BIOSCIENCES, INC. |
发明人 |
BEATON, GRAHAM;TUCCI, FABIO, C.;RAVULA, SATHEESH, B.;SHAH, CHANDRAVADAN, R.;LIU, HIEP |
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