发明名称 |
CORRECTORS ACTING THROUGH MSD1 OF CFTR PROTEIN |
摘要 |
The present disclosure provides methods for treating Cystic Fibrosis in a subject by administering to the subject a corrector agent capable of acting through MSD1 during the biosynthesis of CFTR protein. The disclosure also provides methods of screening for new corrector agents capable of acting through MSD1 during the biosynthesis of a CFTR protein. |
申请公布号 |
CA2907260(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
CA20142907260 |
申请日期 |
2014.03.14 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA CHAPEL HILL;VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
VAN GOOR, FREDRICK F.;HOFFMAN, BETH JENNIFER;DELA ROSA, OXANA ADOLFOVNA;CYR, DOUGLAS |
分类号 |
A61K39/395;A61K31/00;A61K38/00;A61P11/00;C07K14/705;C12Q1/02;C40B30/06;G01N33/48 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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