发明名称 |
COMPOSITIONS COMPRISING ENZYME-CLEAVABLE AMPHETAMINE PRODRUGS AND INHIBITORS THEREOF |
摘要 |
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an amphetamine prodrug that provides enzymatically-controlled release of amphetamine or an amphetamine analog. The composition can further comprise an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of amphetamine or the amphetamine analog from the amphetamine prodrug so as to attenuate enzymatic cleavage of the amphetamine prodrug. |
申请公布号 |
EP2560486(A4) |
申请公布日期 |
2014.09.17 |
申请号 |
EP20110772437 |
申请日期 |
2011.04.08 |
申请人 |
SIGNATURE THERAPEUTICS, INC. |
发明人 |
JENKINS, THOMAS E.;HUSFELD, CRAIG O.;SEROOGY, JULIE D.;WRAY, JONATHAN W. |
分类号 |
C07C279/14;A61K31/16;A61K45/06;A61K47/48;C07C237/22 |
主分类号 |
C07C279/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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