发明名称 |
SWITCHING-TYPE FLUORESCENT NANOPARTICLE PROBE, AND FLUORESCENT MOLECULAR IMAGING METHOD USING SAME |
摘要 |
[Abstract] [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged). [Solution] A fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a polylactic acid-bound cyanine compound comprising: a fluorescent group represented by the formula (I):[Chemical
and a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly. [Selected Figure] Fig.1 |
申请公布号 |
EP2682131(A4) |
申请公布日期 |
2014.09.17 |
申请号 |
EP20120751966 |
申请日期 |
2012.03.01 |
申请人 |
KYOTO UNIVERSITY;SHIMADZU CORPORATION |
发明人 |
SAJI, HIDEO;KIMURA, SHUNSAKU;ONO, MASAHIRO;TEMMA, TAKASHI;HARA, ISAO;OZEKI, EIICHI |
分类号 |
A61K49/00 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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