Novel substituted benzyl derivatives including actvated vinyl group and pharmaceutical compositions for prevention and treatment of neurological diseases through both activating of Nrf2 and inhibiting of producing nitric oxide

摘要

The present invention relates to: a benzyl derivative containing an activated vinyl group; a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the compound as an active ingredient. The benzyl derivative is effective as an agent for preventing and treating neurological disorders caused by nerve cell dysfunction and death, particularly, Parkinson's disease, Alzheimer-type dementia, Huntington's disease, Lou Gehrig's disease, epilepsy, depression, insomnia, anxiety and neurodegenerative diseases through the application of nitric oxide generation inhibition and NF-E2-related factor-2 (Nrf2) activation.