发明名称 |
TREATMENT OF HEMATOLOGIC MALIGNANCIES WITH AN ANTI-CXCR4 ANTIBODY |
摘要 |
The present disclosure provides human monoclonal antibodies that bind specifically to CXCR4 with high affinity. This disclosure also provides a method for treating a subject afflicted with a CXCR4-expressing cancer, in particular a hematological malignancy such as multiple myeloma, acute myeloid leukemia, or non-Hodgkin's lymphoma, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an anti-CXCR4 antibody of the disclosure. The disclosure further provides a kit for treating a cancer in a subject comprising a dose of an anti-CXCR4 antibody and instructions for using the anti-CXCR4 antibody in the therapeutic methods of the disclosure. |
申请公布号 |
EP2776032(A2) |
申请公布日期 |
2014.09.17 |
申请号 |
EP20120787343 |
申请日期 |
2012.11.09 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
KUHNE, MICHELLE R.;PAN, CHIN;CARDARELLI, JOSEPHINE M. |
分类号 |
A61K31/454;A61K31/69;A61K39/395;A61P35/02;A61P35/04;C07K16/28 |
主分类号 |
A61K31/454 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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