发明名称 |
QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE |
摘要 |
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) wherein ring A, RQ, -L-, R1, n, R2, and R3 are as defined herein. The compounds of the invention are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and in methods of treating a patient (preferably a human) for diseases or disorders in which the mGluR2-NAM receptor is involved, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders, by administering to the patient a therapeutically effective amount of a compound of the invention, or a pharmaceutically acceptable salt thereof. The invention is also directed to pharmaceutical compositions comprising a compound of the invention, or a pharmaceutically acceptable salt thereof, (optionally in combination with one or more additional active ingredients), and a pharmaceutically acceptable carrier, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases. |
申请公布号 |
EP2775841(A1) |
申请公布日期 |
2014.09.17 |
申请号 |
EP20120846579 |
申请日期 |
2012.10.26 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BUNGARD, Christopher James;CONVERSO, Antonella;DE LEON, Pablo;HANNEY, Barbara;HARTINGH, Timothy John;MANIKOWSKI, Jesse Josef;MANLEY, Peter, J.;MEISSNER, Robert;MENG, Zhaoyang;PERKINS, James, J.;RUDD, Michael, T.;SHU, Youheng |
分类号 |
A61K31/4725;A61P25/04;A61P25/20;A61P25/28;C07D215/48;C07D401/06;C07D401/14 |
主分类号 |
A61K31/4725 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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