发明名称 |
MONOCLONAL ANTIBODIES THAT BIND B7H6 AND USES THEREOF |
摘要 |
Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6-expressing cells, as well as in diagnostic methods for the detection of B7H6 or B7H6-expressing cells. |
申请公布号 |
EP2510011(B1) |
申请公布日期 |
2014.09.17 |
申请号 |
EP20100813116 |
申请日期 |
2010.12.08 |
申请人 |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE |
发明人 |
PIERRES, MICHEL;VIVIER, ERIC;BARATIN, MYRIAM |
分类号 |
C07K16/30;A61K39/00;A61K39/395;C07K16/28 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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