| 主权项 |
1. A compound having formula (I): and any pharmaceutically acceptable salts thereof, wherein
R1 is a member selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 haloalkyl, C1-8 hydroxyalkyl, C3-8 cycloalkyl, halogen, —CN, —SO2Me and —C(O)NH2;each R2 is a member selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, halogen, —CN and C1-8 alkoxy; or two R2 groups attached to adjacent carbon atoms are optionally connected to form a 5- or 6-member ring which is optionally substituted with additional R2 groups;R3 is a member selected from the group consisting of hydrogen, methyl and C1-4 haloalkyl;R4 is a member selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 haloalkyl and C1-8 hydroxyalkyl;each of the subscripts n is independently an integer from 0 to 3;B is a bond or C(O);Q is a member selected from the group consisting of C, CH, N, O, S, S(O) and SO2;W, X, Y, and Z are independently selected from the group consisting of C, CH and N, but Q and W are not both N;R5 and R6 are absent or are members independently selected from the group consisting of H, —OH, C1-8 alkyl, C1-8 hydroxyalkyl, C1-4 alkoxy-C1-4 alkyl, —C(O)NRaRb, C1-8 alkylene-C(O)NRaRb, —NH—C1-4 alkylene-C(O)NRaRb, —C(O)—C1-4 alkylene-NRaRb, —CO2H and acid isosteres, C1-8 alkylene-CO2H and acid isosteres, —N(Ra)C(O)NRaRb, C1-8 alkylene N(Ra)C(O)NRaRb, —NRaRb, C1-8 alkylene-NRaRb, C1-8 alkoxy, —C(O)ORa, C1-8 alkylene-C(O)ORa, —CN, —C(O)Ra, —SO2Ra and —N(Ra)C(O)Rb;wherein
each Ra and Rb are independently selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 hydroxyalkyl, C1-8 haloalkyl, and C1-8 alkoxy; andR7 is absent or is selected from the group consisting of H, C1-8 alkyl and C1-8 haloalkyl. |
