发明名称 Method for detecting and controlling cancer
摘要 Methods are provided for treating cancer metastasis by administering a therapeutic composition targeting a kinase substrate cascade.
申请公布号 US8834873(B2) 申请公布日期 2014.09.16
申请号 US200712513040 申请日期 2007.10.31
申请人 George Mason Research Foundation, Inc.;Istituto Superiore di Sanita 发明人 Petricoin, III Emanuel F.;Pierobon Mariaelena;Calvert Valerie;Liotta Lance A.
分类号 A61K39/395;C07K16/22;G01N33/574 主分类号 A61K39/395
代理机构 代理人 Karny Geoffrey M.
主权项 1. A method for treating a patient with colorectal cancer that has metastasized to the patient's liver and/or lung comprising the step of administering to the patient a therapeutically effective amount of one or more drugs that target at least two of the following proteins, if two or more of the proteins are found to be elevated in a sample of the metastatic cancer from the patient: pAKT, pSTAT3, pVEGFR, pFKHR-FICHRL1, pcKit, pShc, pSMAD2, pSrc, pSTAT5, pAbl, pJak1, pPyk2, pPDGFRb, pPRAS40, and pEGFR, wherein the drugs are selected from the group consisting of Imatinib mesylate, Bevacizumab, Erlotinib hydrochloride, Panitumumab, Lapatinib, an akt inhibitor, and a PI3 kinase inhibitor.
地址 Fairfax VA US