Sustained release implant for granisetron

摘要

The main goals of the invention are to develop the long-term release of Granisetron injection implant composition with biodegradable polymer and to develop relative processing. Granisetron is mixed with different biodegradable polymers, and then hot melt extrusion technique with different diameter, temperature, rate of extrusion and holding time is applied to make implant. In vitro dissolution of the Granisetron injection implant composition shows the component continued release of the drug for over 7 days.

主权项

1. A solid implant sustained release pharmaceutical composition comprising:
a pharmaceutically acceptable salt of Granisetron, and a mixture of biodegradable polymers, said mixture comprising poly(lactic-co-glycolic acid) (PLGA) and poly(lactic-co-glycolic acid)-polyethylene glycol (PLGA-PEG) in a weight ratio of 7.5:1 to 5:3,
wherein the weight ratio of (a) and (b) is between 1:1 to 2:5.