Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application

摘要

The disclosure relates to hexafluoroisopropyl carbamate derivatives of general formula (I):;
in which:
R, Z, A, m, and n are as defined in the disclosure;in the form of the base or of an addition salt with an acid, and to the preparation process and therapeutic application thereof.

主权项

1. A compound of formula (I): wherein: R represents an R1 group unsubstituted or substituted by one or more substituents independently selected from the group consisting of R2 and R3; R1 represents an aryl or heteroaryl group; R2 represents a halogen atom or a cyano, nitro, oxo, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxyl, (C1-C6)alkylthio, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, (C1-C6)haloalkylthio, NR4R5, NR4COR5, NR4SO2R5, COR4, CO2R4, CONR4R5, SO2R4, SO2NR4R5, or benzyloxy group; R3 represents a monocyclic aryl or heteroaryl group which can be substituted by one or more R2 groups which are identical to or different from one another; R4 and R5 represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl group or forms, with the nitrogen atom or the N—CO or N—SO2 fragment which carriers them, a heterocycle optionally substituted by a (C1-C6)alkyl or benzyl group; Z represents a bond, a (C1-C6)alkylene group, a (C2-C6)alkenylene group, a (C2-C6)alkynylene group, an O—(C1-C6)alkylene group or an N(RA)—(C1-C6)alkylene group; A represents a bond, an oxygen atom, a sulphur atom, an N(RA) group, an N(RA)—(C1-C6)alkylene group, a CON(RA) group, a CON(RA)—(C1-C6)alkylene group, an SO2N(RA) group, an SO2N(RA)—(C1-C6)alkylene group, an OCON(RA) group, an OCON(RA)—(C1-C6)alkylene group, an N(RB)CON(RA) group, an N(RB)CON(RA)—(C1-C6)alkylene group, an N(RB)SO2N(RA) group, an N(RB)SO2N(RA)—(C1-C6)alkylene group, an O—(C1-C6)alkylene group, an N(RB)CO2 group, an N(RB)CO2—(C1-C6)alkylene group, an S—(C1-C6)alkylene group, an SO2 group, an SO2(C1-C6)alkylene group, an N(RB)SO2 group, an N(RB)SO2—(C1-C6)alkylene group, a CO group, a CO—(C1-C6)alkylene group, an N(RB)CO group, an N(RB)CO—(C1-C6)alkylene group, an SO2N(RB)CO group, an SO2N(RB)CO—(C1-C6)alkylene group, an SO2N(RB)CON(RA) group or an SO2N(RB)CON(RA)—(C1-C6)alkylene group; RA and RB represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl group; and m and n represent, independently of one another, an integer equal to 0 or 1, in the form of the base or of an addition salt with an acid.