| 摘要 |
A system, apparatus and methods are provided for extra-corporeal blood treatment, and in particular for establishing and maintaining a neck down differential body temperature, while maintaining near normal brain temperatures, to protect the brain from extended or extreme hypothermia or hyperthermia. A blood treatment apparatus and system is provided for differential control of brain temperature and body temperature below the neck. For example, a first bypass circuit with heat exchanger for brain blood circulation maintains a near normal blood temperature, while a second bypass circuit for below the neck blood circulation provides for thermal treatment to induce a temperature differential, e.g. hyperthermia or hypothermia, relative to brain circulation. Such systems and apparatus have application, for example, for diagnostic and therapeutic treatments using hyperthermia, particularly for treatments of extended duration or at elevated temperatures above 42° C., for example, hyperthermia for treatment of cancer, infectious bacterial or viral diseases. |
| 主权项 |
1. A system for extracorporeal blood treatment characterized by:
i) an arterial blood flow bypass circuit having input means (101) for receiving arterial blood flow from the body and output means (102) for coupling to a left or right or both carotid arterial blood flows to the brain; a first heat exchange means (103) for regulating a temperature of said carotid bypass blood flow to the brain; pump means (104) for controlling a flow rate of said carotid blood flow to the brain; sensor means (114) for monitoring temperature of output blood flows, and ii) a second heat exchange means for concurrently heating or cooling the patient from the neck down to a desired temperature iii) control means (300) for concurrently monitoring and controlling the arterial blood flow bypass circuit in order to obtain a desired brain temperature and said second heat exchange means in order to obtain a desired core body temperature,
wherein the second heat exchange means comprises a venous blood flow bypass circuit having input means (501) for receiving venous blood flow from the brain, and output means (502) for coupling to venous blood flow to the body, heat exchanger (103) configured to regulate the temperature of said venous blood flow from the brain before returning it to the body; pump means (104) for controlling a flow rate and pressure of said venous bypass blood flow; sensor means (114) for monitoring temperature of output blood flows, and wherein said control means (300) further provides for controlling temperature and flow rate of the output venous blood flow to the body. |
