发明名称 |
Method for producing fluorosulfuric acid ester |
摘要 |
Fluorosulfuric acid esters can be produced by reacting alcohols with sulfuryl fluoride (SO2F2) in the presence of a base and water. As a substrate thereof, optically active secondary alcohols are preferable, and optically active α-hydroxyesters and optically active 4-hydroxyprolines are particularly preferable. By performing the reaction in a two-phase system in the presence of a reaction solvent immiscible with water, a desired reaction proceeds particularly well. The present invention is a production method solving all the problems involved in conventional techniques while being industrially practicable. |
申请公布号 |
US8835669(B2) |
申请公布日期 |
2014.09.16 |
申请号 |
US200913125452 |
申请日期 |
2009.10.15 |
申请人 |
Central Glass Company, Limited |
发明人 |
Ishii Akihiro;Yasumoto Manabu |
分类号 |
C07C315/02;C07D207/16;C07B53/00;C07C303/24 |
主分类号 |
C07C315/02 |
代理机构 |
Crowell & Moring LLP |
代理人 |
Crowell & Moring LLP |
主权项 |
1. A method for producing a fluorosulfuric acid ester represented by the formulaby reacting an alcohol represented by the formulawith sulfuryl fluoride (SO2F2) in the presence of a base and water,
wherein the reaction is performed in a two-phase system in the presence of a reaction solvent immiscible with water, the base is triethylamine and potassium carbonate, and the reaction solvent immiscible with water is toluene. |
地址 |
Ube-shi JP |