发明名称 |
β-mannosylceramide and stimulation of NKT cell anti-tumor immunity |
摘要 |
β-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of α-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising β-mannosylceramide, as well as methods of treatment of tumors are also provided. |
申请公布号 |
US8835613(B2) |
申请公布日期 |
2014.09.16 |
申请号 |
US201113582612 |
申请日期 |
2011.03.11 |
申请人 |
The United States of America, as represented by the Secretary, Department of Health and Human Services;The University of Birmingham, of Edgbaston |
发明人 |
Berzofsky Jay A.;O'Konek Jessica J.;Terabe Masaki;Illarionov Petr;Besra Gurdyal S. |
分类号 |
A61K31/7032;A61K38/19;A61K39/00;A61K38/20;A61K39/395;C07H15/04;A61P37/04;A61K31/7004 |
主分类号 |
A61K31/7032 |
代理机构 |
Leydig, Voit & Mayer |
代理人 |
Leydig, Voit & Mayer |
主权项 |
1. A composition comprising a β-mannosylceramide (β-ManCer) or salt or solvate thereof in a pharmaceutically acceptable carrier, wherein the β-ManCer consists of: |
地址 |
Washington DC US |