发明名称 β-mannosylceramide and stimulation of NKT cell anti-tumor immunity
摘要 β-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of α-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising β-mannosylceramide, as well as methods of treatment of tumors are also provided.
申请公布号 US8835613(B2) 申请公布日期 2014.09.16
申请号 US201113582612 申请日期 2011.03.11
申请人 The United States of America, as represented by the Secretary, Department of Health and Human Services;The University of Birmingham, of Edgbaston 发明人 Berzofsky Jay A.;O'Konek Jessica J.;Terabe Masaki;Illarionov Petr;Besra Gurdyal S.
分类号 A61K31/7032;A61K38/19;A61K39/00;A61K38/20;A61K39/395;C07H15/04;A61P37/04;A61K31/7004 主分类号 A61K31/7032
代理机构 Leydig, Voit & Mayer 代理人 Leydig, Voit & Mayer
主权项 1. A composition comprising a β-mannosylceramide (β-ManCer) or salt or solvate thereof in a pharmaceutically acceptable carrier, wherein the β-ManCer consists of:
地址 Washington DC US