Treatment of vaginal atrophy in women with cardiovascular pathology risk

摘要

The present invention relates to the use of estriol in the preparation of a pharmaceutical formulation for vaginal administration with the capacity to self-limit the absorption of estriol, for the prevention and/or the treatment of urogenital atrophy in women said women having a high probability of suffering from a cardiovascular pathology or suffering or having suffered from a cardiovascular pathology.

主权项

1. A method of treatment of urogenital atrophy in woman comprising the vaginal administration of pharmaceutical estriol formulations with the capacity of self-limiting the absorption of estriol to a woman in need thereof, wherein said women suffer or have suffered a venous thromboembolic pathology, a coronary or cerebrovascular disease or migraine with aura and wherein the pharmaceutical formulation provides a dose of estriol less than or equal to 0.3 mg/day.