Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate

摘要

Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that impart specific biological activity thereto. The surfaces and materials are useful in medical diagnostics, biomaterials and bioprocessing, tissue engineering, and drug delivery.

主权项

1. A substrate having a modified surface, comprising,
(a) a polymer attached to a surface of a substrate, wherein the polymer comprises a plurality of carboxylic acid groups and a plurality of positive charged groups, and wherein the polymer is substantially electronically neutral; and (b) a target binding partner, covalently coupled to the polymer, and wherein the target binding partner has affinity toward a target molecule.