Process for the preparation of enantiomerically pure <i>tert</i>-leucine

摘要

Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.

主权项

1. A process for the preparation of enantiomerically pure tertiary-leucine which is L-tert-leucine by resolution of (DL)-tertiary-leucine by forming a diastereomeric salt using a resolving agent selected from optically active tartaric acid derivatives, comprising:
(a) dissolving (DL)-tent-leucine in a polar solvent and treating it with dibenzoyl-d-tartaric acid to create a suspension, (b) filtering the suspension to obtain selectively L-tert-leucine dibenzoyl-d-tartrate salt, (c) treating the tartrate salt with an acid to obtain an acid salt of L-tert-leucine and free dibenzoyl-d-tartaric acid, and (d) neutralizing the acid salt to obtain free L-tert-leucine.