Ocular radiosurgery

摘要

A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

主权项

1. A method of planning radiation therapy for an eye, comprising:
preparing a treatment plan for delivery of an actual dose of radiation to a target region of the eye from at least one x-ray radiation beam, the preparing comprising:
determining a first estimated dose of radiation to be delivered from an x-ray radiation source outside the eye to the target region;determining a second estimated dose of radiation, to be received by a second region of the eye from the x-ray radiation source, the second estimated dose of radiation being equal to or less than about 40 percent of the first estimated dose; and wherein the treatment plan comprises at least one of a width of the at least one radiation beam, a distance from the radiation source to the target region, a trajectory of the beam, and the first estimated dose of radiation; and wherein the at least one of the width of the at least one radiation beam, the distance from the radiation source to the target region, and the trajectory of the beam is selected to effect delivery of the first estimated dose to the target region and the second estimated dose to the second region; and outputting information indicative of the treatment plan to an output module.