| 发明名称 | SIR2 regulation | ||
| 摘要 | Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed. | ||
| 申请公布号 | US8835467(B2) | 申请公布日期 | 2014.09.16 |
| 申请号 | US201313747543 | 申请日期 | 2013.01.23 |
| 申请人 | Albert Einstein College of Medicine of Yeshiva University | 发明人 | Schramm Vern L.;Sauve Anthony A. |
| 分类号 | A61K31/445;C12Q1/34;C07D241/24;C07D213/83;A61K38/00;A61K31/4965;A61K31/455;A61K31/166;C07D213/81 | 主分类号 | A61K31/445 |
| 代理机构 | Amster, Rothstein & Ebenstein LLP | 代理人 | Amster, Rothstein & Ebenstein LLP |
| 主权项 | 1. A composition formulated for topical administration comprising isonicotinamide in an amount effective to increase protein deacetylation by a SIR2 enzyme in a living cell. | ||
| 地址 | Bronx NY US | ||