发明名称 |
METHOD OF IDENTIFYING MEMBRANE IG SPECIFIC ANTIBODIES AND USE THEREOF FOR TARGETING IMMUNOGLOBULIN-PRODUCING PRECURSOR CELLS |
摘要 |
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell -mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. |
申请公布号 |
CA2624081(C) |
申请公布日期 |
2014.09.16 |
申请号 |
CA20062624081 |
申请日期 |
2006.09.28 |
申请人 |
MEDIMMUNE, INC. |
发明人 |
WU, HERREN;KIENER, PETER;CHOWDHURY, PARTHA S.;YOUNG, JAMES F. |
分类号 |
C12N15/13;A61K47/48;A61P11/06;A61P37/08;C07K16/42;C12N5/10;C40B30/04;C40B40/10 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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