发明名称 |
Needle array assembly and method for delivering therapeutic agents |
摘要 |
A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment. |
申请公布号 |
US8834428(B2) |
申请公布日期 |
2014.09.16 |
申请号 |
US201113330044 |
申请日期 |
2011.12.19 |
申请人 |
Fred Hutchinson Cancer Research Center |
发明人 |
Bahrami S. Bahram;Veiseh Mandana;Olson James |
分类号 |
A61M5/00;A61M5/32;A61M5/168;A61M5/145 |
主分类号 |
A61M5/00 |
代理机构 |
Wilson Sonsini Goodrich & Rosati |
代理人 |
Wilson Sonsini Goodrich & Rosati |
主权项 |
1. A method of evaluating one or more candidate agents, wherein at least one of the one or more candidate agents is a drug, comprising: introducing the one or more candidate agents to one or more positions in a solid tissue, and; evaluating effectiveness of the candidate agents on the solid tissue, wherein the introducing step is in vivo, and wherein the solid tissue is a tumor. |
地址 |
Seattle WA US |