发明名称 Fungicidal heterocyclic compounds
摘要 Disclosed are compounds of Formula 1 and Formula 1A including all stereoisomers, N-oxides, and salts thereof,; wherein E, Y1, Y2, Y3, G, J, X1 and X2 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 or Formula 1A and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.
申请公布号 US8835427(B2) 申请公布日期 2014.09.16
申请号 US201113518943 申请日期 2011.01.07
申请人 E I du Pont de Nemours and Company 发明人 Liepa Andris Juris;Pasteris Robert James;Stevenson Thomas Martin
分类号 C07D417/04;C07D487/04;A01N43/80;A01N43/90 主分类号 C07D417/04
代理机构 代理人 Lett Renee M.
主权项 1. A compound selected from Formula 1 or Formula 1A, N-oxides and salts thereof,wherein E is a radical selected from the group consisting of Y1 is —N═C(R14)—, —C(R14)═N— or a ring-forming chain consisting of 2 chain members wherein one chain member is —C(R14)2— and the second chain member is selected from —C(R14)2—, —O—, —S—, —N(R23)— and —C(═O)—; Y2 is a ring member selected from —C(R14)— and —N—; Y3 is —N═C(R14)—, —C(R14)═N— or a ring-forming chain consisting of 2 chain members wherein one chain member is —C(R14)2— and the second chain member is selected from —C(R14)2—, —O—, —S—, —N(R23)— and —C(═O)—; or Y3 is —C(R14)2N═C(R14)—, —C(R14)2C(R14)═N—, —N═C(R14)C(R14)2—, —C(R14)═NC(R14)2— or a ring-forming chain consisting of 3 chain members wherein two chain members are —C(R14)2— and the third chain member is selected from —C(R14)2—, —O—, —S—, —N(R23)— and —C(═O)—; X1 and X2 are each independently a ring member selected from —C(R14)— and —O—; G is  wherein the bond projecting to the left is bonded to Y2 in Formula 1 or Formula 1A, and the bond projecting to the right is bonded to J in Formula 1 or Formula 1A; each R29a is independently selected from H and R29; J is  wherein the bond shown projecting to the left is bonded to G in Formula 1 or Formula 1A and to an available carbon or nitrogen atom ring member in the J ring; and x is an integer from 0 to 5; A1 is CHR15, NR16 or C(═O); A2 is —O—, —S—, —N(R7)—, —C(R8)2—, —OC(R8)2—, —SC(R8)2— or —N(R7)C(R8)2—, wherein the bond projecting to the left is connected to —N═C(R2)(R3), and the bond projecting to the right is connected to —C(R4)(R5)—; W1 and W2 are each independently O or S; W3 is OR24, SR25, NR26R27 or R28; R1a and R1c independently are an optionally substituted phenyl, an optionally substituted naphthalenyl or an optionally substituted 5- to 6-membered heteroaromatic ring, then the optional substituents on the phenyl, naphthalenyl or 5- or 6-membered heteroaromatic ring are independently selected from R33a on carbon ring members and R33b on nitrogen ring members; or pyrrolidinyl, piperidinyl or morpholinyl, cyano, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 haloalkyl, C2-C8 haloalkenyl, C2-C8 haloalkynyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, C4-C10 alkylcycloalkyl, C4-C10 cycloalkylalkyl, C4-C10 halocycloalkylalkyl, C5-C10 alkylcycloalkylalkyl, C2-C8 alkoxyalkyl, C2-C8 haloalkoxyalkyl, C4-C10 cycloalkoxyalkyl, C3-C10 alkoxyalkoxyalkyl, C2-C8 alkylthioalkyl, C2-C8 haloalkylthioalkyl, C2-C8 alkylsulfinylalkyl, C2-C8 alkylsulfonylalkyl, C3-C8 alkoxycarbonylalkyl, C3-C8 haloalkoxycarbonylalkyl, C2-C8 alkylaminoalkyl, C3-C10 dialkylaminoalkyl, C2-C8 haloalkylaminoalkyl, C4-C10 cycloalkylaminoalkyl, C1-C8 alkoxy, C1-C8 haloalkoxy, C3-C8 cycloalkoxy, C3-C8 halocycloalkoxy, C4-C10 cycloalkylalkoxy, C2-C8 alkenyloxy, C2-C8 haloalkenyloxy, C2-C8 alkynyloxy, C3-C8 haloalkynyloxy, C2-C8 alkoxyalkoxy, C2-C8 alkylcarbonyloxy, C2-C8 haloalkylcarbonyloxy, C1-C8 alkylthio, C1-C8 haloalkylthio, C3-C8 cycloalkylthio, C3-C10 trialkylsilyl, C1-C8 alkylamino, C2-C8 dialkylamino, C1-C8 haloalkylamino, C2-C8 halodialkylamino, C3-C8 cycloalkylamino, C2-C8 alkylcarbonylamino, C2-C8 haloalkylcarbonylamino, C1-C8 alkylsulfonylamino or C1-C8 halo alkylsulfonylamino; R2 is H, halogen, cyano, amino, —CHO, —C(═O)OH, —C(═O)NH2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C4-C6 alkylcycloalkyl, C4-C6 cycloalkylalkyl, C4-C6 halocycloalkylalkyl, C3-C6 cycloalkenyl, C3-C6 halocycloalkenyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 alkylaminoalkyl, C3-C6 dialkylaminoalkyl, C2-C6 haloalkylaminoalkyl, C2-C6 alkylcarbonyl, C2-C6 haloalkylcarbonyl, C4-C6 cycloalkylcarbonyl, C2-C6 alkoxycarbonyl, C4-C6 cycloalkoxycarbonyl, C5-C6 cycloalkylalkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C6 dialkylaminocarbonyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C6 cycloalkoxy, C3-C6 halocycloalkoxy, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C2-C6 alkynyloxy, C3-C6 haloalkynyloxy, C2-C6 alkoxyalkoxy, C2-C6 alkylcarbonyloxy, C2-C6 haloalkylcarbonyloxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C3-C6 cycloalkylthio, C1-C6 alkylamino, C2-C6 dialkylamino, C1-C6 haloalkylamino, C2-C6 halodialkylamino, C3-C6 cycloalkylamino, C2-C6 alkylcarbonylamino, C2-C6 haloalkylcarbonylamino, C1-C6 alkylsulfonylamino or C1-C6 haloalkylsulfonylamino; R3 is H, halogen, cyano, hydroxy, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy or C1-C3 haloalkoxy; or R2 and R3 are taken together with the carbon atom to which they are attached to form a 3-to 7-membered ring containing ring members selected from carbon atoms and up to 4 heteroatoms independently selected from up to 2 O, up to 2 S, up to 2 N and up to 2 Si atoms, wherein up to 3 carbon atom ring members are independently selected from C(═O) and C(═S), the sulfur atom ring members are independently selected from S(═O)s(═NR11)f, and the silicon atom ring members are independently selected from SiR9R10, the ring optionally substituted with up to 4 substituents independently selected from halogen, cyano, C1-C2 alkyl, C1-C2 haloalkyl, C1-C2 alkoxy and C1-C2 haloalkoxy on carbon atom ring members and cyano, C1-C2 alkyl and C1-C2 alkoxy on nitrogen atom ring members; R4 is optionally substituted phenyl, optionally substituted naphthalenyl or an optionally substituted 5- to 6-membered heteroaromatic ring; or H, halogen, cyano, hydroxy, —CHO, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C2-C4 alkoxyalkyl, C2-C4 alkylthioalkyl, C2-C4 alkylsulfinylalkyl, C2-C4 alkylsulfonylalkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl, C2-C5 alkylaminocarbonyl, C3-C5 dialkylaminocarbonyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylsulfonyl, C2-C4 alkylcarbonyloxy, C2-C4 haloalkylcarbonyloxy, C2-C5 alkoxycarbonyloxy, C2-C5 alkylaminocarbonyloxy or C3-C5 dialkylaminocarbonyloxy; R5 is H, C1-C3 alkyl or C1-C3 haloalkyl; each R6 is independently H, halogen, cyano, hydroxy, amino, nitro, —CHO, —C(═O)OH, —C(═O)NH2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, C4-C10 alkylcycloalkyl, C4-C10 cycloalkylalkyl, C6-C14 cycloalkylcycloalkyl, C4-C10 halocycloalkylalkyl, C5-C10 alkylcycloalkylalkyl, C3-C8 cycloalkenyl, C3-C8 halocycloalkenyl, C2-C6 alkoxyalkyl, C4-C10 cycloalkoxyalkyl, C3-C8 alkoxyalkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 alkylaminoalkyl, C3-C8 dialkylaminoalkyl, C2-C6 haloalkylaminoalkyl, C4-C10 cycloalkylaminoalkyl, C2-C6 alkylcarbonyl, C2-C6 haloalkylcarbonyl, C4-C8 cycloalkylcarbonyl, C2-C6 alkoxycarbonyl, C4-C8 cycloalkoxycarbonyl, C5-C10 cycloalkylalkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl, C4-C8 cycloalkylaminocarbonyl, C2-C6 haloalkoxyalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C8 cycloalkoxy, C3-C8 halocycloalkoxy, C4-C10 cycloalkylalkoxy, C2-C6 alkenyloxy, C2-C6 haloalkenyloxy, C2-C6 alkynyloxy, C2-C6 haloalkynyloxy, C2-C6 alkoxyalkoxy, C2-C6 alkylcarbonyloxy, C2-C6 haloalkylcarbonyloxy, C4-C8 cycloalkylcarbonyloxy, C3-C6 alkylcarbonylalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C3-C8 cycloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1 -C6 haloalkylsulfonyl, C3-C8 cycloalkylsulfonyl, C3-C10 trialkylsilyl, C1-C6 alkylsulfonylamino, C1-C6 haloalkylsulfonylamino, —NR20R21 or —ZQ; each Z is independently a direct bond, O, C(═O), S(O)m, CH(R12) or N(R13); each Q is independently phenyl, benzyl, naphthalenyl, a 5- to 6-membered heteroaromatic ring or an 8- to 1 1-membered heteroaromatic bicyclic ring system, each optionally substituted with up to 2 substituents independently selected from R6b on carbon and nitrogen atom ring members, and each optionally substituted with up to 5 substituents independently selected from R6a on carbon atom ring members and selected from C1-C3 alkyl, C2-C3 alkylcarbonyl, C2-C3 alkoxycarbonyl or C1-C3 alkoxy on nitrogen atom ring members; or a 3- to 7-membered nonaromatic carbocyclic ring, a 5- to 7-membered nonaromatic heterocyclic ring or an 8- to 11-membered nonaromatic bicyclic ring system, each ring or ring system containing ring members selected from carbon atoms and up to 4 heteroatoms independently selected from up to 2 O, up to 2 S, up to 4 N and up to 2 Si atoms, wherein up to 3 carbon atom ring members are independently selected from C(═O) and C(═S), the sulfur atom ring members are independently selected from S(═O)S(═NR11)f, and the silicon atom ring members are independently selected from SiR9R10, each ring or ring system optionally substituted with up to 2 substituents independently selected from R6b on carbon and nitrogen atom ring members, and each ring or ring system optionally substituted with up to 5 substituents independently selected from R6b on carbon atom ring members and selected from C1-C3 alkyl, C2-C3 alkylcarbonyl, C2-C3 alkoxycarbonyl and C1-C3 alkoxy on nitrogen atom ring members; each R6a is independently halogen, hydroxy, amino, cyano, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C10 cycloalkylalkyl, C4-C10 alkylcycloalkyl, C5-C10 alkylcycloalkylalkyl, C6-C14 cycloalkylcycloalkyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C2-C4 alkoxyalkyl, C1-C4 hydroxyalkyl, C2-C4 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylcarbonyloxy, C2-C6 alkylcarbonylthio, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-C6 trialkylsilyl; or each R6b is independently phenyl optionally substituted with up to 3 substituents independently selected from halogen, cyano, C1-C2 alkyl, C1-C2 haloalkyl, C1-C2 alkoxy and C1-C2 haloalkoxy; or a 5- to 6-membered heteroaromatic ring containing ring members selected from carbon atoms and up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, and optionally substituted with up to 3 substituents independently selected from halogen, cyano, C1-C2 alkyl, C1-C2 haloalkyl, C1-C2 alkoxy and C1-C2 haloalkoxy on carbon atom ring members and cyano, C1-C2 alkyl and C1-C2 alkoxy on nitrogen atom ring members; or a 3- to 7-membered nonaromatic ring containing ring members selected from carbon atoms and up to 4 heteroatoms independently selected from up to 2 O, up to 2 S and up to 4 N atoms, wherein up to 3 carbon atom ring members are independently selected from C(═O) and C(═5), the ring optionally substituted with up to 3 substituents independently selected from halogen, cyano, C1-C2 alkyl, C1-C2 haloalkyl, C1-C2 alkoxy and C1-C2 haloalkoxy on carbon atom ring members and cyano, C1-C2 alkyl and C1-C2 alkoxy on nitrogen atom ring members; R7 is H, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C2-C4 alkoxyalkyl, C2-C4 alkylthioalkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C4 alkoxycarbonyl, C2-C4 alkylaminocarbonyl, C3-C5 dialkylaminocarbonyl, C1-C4 alkylsulfonyl or C1-C4 haloalkylsulfonyl; or R3 and R7 are taken together with the linking atoms to which they are attached to form a 5-to 7-membered partially saturated ring containing ring members, in addition to the linking atoms, selected from carbon atoms and up to 3 heteroatoms independently selected from up to 1 O, up to 1 S and up to 1 N atom, the ring optionally substituted with up to 3 substituents independently selected from halogen, cyano, nitro, C1-C2 alkyl, C1-C2 haloalkyl, C1-C2 alkoxy and C1-C2 haloalkoxy on carbon atom ring members and cyano, C1-C2 alkyl and C1-C2 alkoxy on nitrogen atom ring members; each R8 is independently H, C1-C3 alkyl or C1-C3 haloalkyl; each R9 and R10 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C5 cycloalkyl, C3-C6 halocycloalkyl, C4-C10 cycloalkylalkyl, C4-C7 alkylcycloalkyl, C5-C7 alkylcycloalkylalkyl, C1-C5 haloalkyl, C1-C5 alkoxy or C1-C5 haloalkoxy; each R11 is independently H, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C3-C8 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylamino, C2-C8 dialkylamino, C1-C6 haloalkylamino or phenyl; each R12 is independently H, C1-C4 alkyl or C1-C4 haloalkyl; R13 is H, C1-C4 alkyl, C1-C4 haloalkyl, C3-C6 cycloalkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C4 alkoxycarbonyl or C2-C4 haloalkoxycarbonyl; each R14 is independently H, halogen, cyano, hydroxy, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 haloalkyl or C1-C4 alkoxy; R15 is H, halogen, cyano, hydroxy, —CHO, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C2-C4 alkoxyalkyl, C2-C4 alkylthioalkyl, C2-C4 alkylsulfinylalkyl, C2-C4 alkylsulfonylalkyl, C3-C5 alkoxycarbonylalkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl, C2-C5 alkylaminocarbonyl, C3-C5 dialkylaminocarbonyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 haloalkylthio, C1-C4 alkylsulfinyl, C1-C4 haloalkylsulfinyl, C1-C4 alkylsulfonyl or C1-C4 haloalkylsulfonyl; R16 is H, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 haloalkyl, C2-C4 haloalkenyl, C2-C4 haloalkynyl, C2-C4 alkoxyalkyl, C2-C4 alkylthioalkyl, C2-C4 alkylsulfinylalkyl, C2-C4 alkylsulfonylalkyl, C2-C4 alkylcarbonyl, C2-C4 haloalkylcarbonyl, C2-C5 alkoxycarbonyl, C3-C5 alkoxycarbonylalkyl, C2-C5 alkylaminocarbonyl, C3-C5 dialkylaminocarbonyl, C1-C4 alkylsulfonyl or C1-C4 haloalkylsulfonyl; each R20 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C2-C6 alkylcarbonyl, C2-C6 haloalkylcarbonyl, C2-C6 alkoxycarbonyl or C2-C6 haloalkoxycarbonyl; each R21 is independently C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C2-C6 alkylcarbonyl, C2-C6 haloalkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 haloalkoxycarbonyl or —Z1Q; each Z1 is independently O, C(═O), S(O)m or CH(R12); each R23 is independently H, —CHO, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 haloalkyl, C1-C3 alkylcarbonyl, C2-C4 alkoxyalkyl, C2-C4 alkoxycarbonyl, C2-C4 alkylaminocarbonyl, C4-C7 dialkylaminocarbonyl or C2-C4 alkylsulfonyl; each R24 and R25 is independently C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C1-C6 haloalkyl, C3-C6 haloalkenyl, C3-C6 haloalkynyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C4-C8 alkylcycloalkyl, C4-C8 cycloalkylalkyl, C4-C8 halocycloalkylalkyl, C5-C8 alkylcycloalkylalkyl, C2-C6 alkoxyalkyl, C4-C8 cycloalkoxyalkyl, C3-C6 alkoxyalkoxyalkyl, C2-C6 alkylthioalkyl, C2-C6 alkylsulfinylalkyl, C2-C6 alkylsulfonylalkyl, C2-C6 alkylaminoalkyl, C3-C6 dialkylaminoalkyl, C2-C6 haloalkylaminoalkyl, C4-C8 cycloalkylaminoalkyl, C2-C6 alkylcarbonyl, C2-C6 haloalkylcarbonyl, C4-C8 cycloalkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C4-C8 cycloalkylaminocarbonyl; R26 is H, cyano, hydroxy, amino, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C1-C6 haloalkyl, C3-C6 haloalkenyl, C3-C6 haloalkynyl, C3-C6 cycloalkyl, C4-C8 cycloalkylalkyl, C2-C6 alkoxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C2-C6 alkylcarbonyl, C2-C6 haloalkylcarbonyl, C1-C6 alkylamino, C2-C8 dialkylamino, C1-C6 haloalkylamino or C2-C8 halodialkylamino; R27 is H, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C1-C6 haloalkyl or C3-C6 cycloalkyl; or R26 and R27 are taken together as —(CH2)4—, —(CH2)5— or —(CH2)2O(CH2)2—; R28 is H, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C2-C4 alkoxyalkyl, C2-C4 alkylcarbonyl, C2-C4 alkoxycarbonyl, C2-C3 alkylaminocarbonyl or C3-C6 dialkylaminocarbonyl; each R29 is independently halogen, C1-C3 alkyl or C1-C3 haloalkyl; each R33a is independently halogen, cyano, hydroxy, amino, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C10 cycloalkylalkyl, C4-C10, alkylcycloalkyl, C5-C10, alkylcycloalkylalkyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, C3-C6 halocycloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 haloalkylthio, C1-C4 haloalkylsulfinyl, C1-C4 haloalkylsulfonyl, C1-C4 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C2-C4 alkoxyalkyl, C1-C4 hydroxyalkyl, C2-C4 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylcarbonyloxy, C2-C6 alkylcarbonylthio, C2-C6 alkylaminocarbonyl, C3-C8 dialkylaminocarbonyl or C3-C6 trialkylsilyl; each R33b is independently C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, C3-C6 haloalkenyl, C3-C6 haloalkynyl, C3-C6 halocycloalkyl or C2-C 4 alkoxyalkyl; each m is independently 0, 1 or 2; and s and f are independently 0, 1 or 2 in each instance of S(═O)s(═NR11)f, provided that the sum of s and f is 1 or 2; provided that: (a) when Y1 is a ring-forming chain consisting of 2 chain members and Y3 is a ring-forming chain consisting of 2 or 3 chain members, then at least one of the chain members of Y1 or Y3 is other than C(R14)2; (b) when Y1 is a ring-forming chain consisting of 2 chain members or Y3 is a ring-forming chain consisting of 2 or 3 chain members and when a chain member is —C(═O)—, then said chain member is bonded to other than N-E in Formula 1; (c) when X1 is —O—, then X2 is —C(R14)— and the ring is fully saturated; and when X2 is —O—, then X1 is —C(R14)— and the ring is fully saturated; (d) when Y2 is N, then the heterocyclic ring G is bonded to Y2 through a carbon atom; and (f) when R15 is hydroxy, then R1a is bonded through a carbon atom to A in Formula 1 or Formula 1A.
地址 Wilmington DE US