| 主权项 |
1. A compound comprising the formula X—Y—Z, wherein X designates a calcitonin gene-related peptide (CGRP) compound from which, formally, a hydrogen has been removed from one of the amino groups present in an amino acid residue; Y is a linker elected from the group consisting of the six groups of the following formulae: wherein m is 0, 1, 2, 3, 4, 5 or 6; n is 1, 2 or 3; s is 0, 1, 2 or 3; and p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 or 23, and wherein the carbonyl end of these moieties is connected to the CGRP compound (designated X) and the amino end of these moieties is connected to the acyl group (designated Z); and Z is an acyl group; wherein the —Y—Z moiety is connected to an amino group present at the N terminal amino acid residue of the CGRP compound. |
