| 发明名称 | Influenza A H1N1 subtype-specific aptamer and applications thereof | ||
| 摘要 | The present invention provides an Influenza A H1N1 subtype-specific aptamer. The aptamer was selected in vitro using SELEX and a microfluidic chip system. The aptamer is stable, establishing sensitivity about 100 times higher than antibody and high specificity to Influenza A H1N1 subtype. Thus, the aptamer can be effective in detection of H1N1 influenza virus. | ||
| 申请公布号 | US8835624(B1) | 申请公布日期 | 2014.09.16 |
| 申请号 | US201414185196 | 申请日期 | 2014.02.20 |
| 申请人 | National Tsing Hua University | 发明人 | Lee Gwo-Bin;Liou Tong-Minn;Wang Chih-Hung;Lai Hsien-Chih |
| 分类号 | C07H21/04;C12Q1/68;C12N5/00;C12N15/00 | 主分类号 | C07H21/04 |
| 代理机构 | WPAT, P.C. | 代理人 | WPAT, P.C. ;King Anthony;Yang Kay |
| 主权项 | 1. An aptamer comprising (i) the nucleic acid sequence of SEQ ID NO: 2 or a complement thereof, or (ii) 40 consecutive bases sequence of the nucleic acid sequence of SEQ ID NO: 2 or a complement thereof, wherein the 40 consecutive bases sequence is the nucleic acid sequence of SEQ ID NO: 1 and the aptamer specifically binds to Influenza A H1N1 subtype virus. | ||
| 地址 | Hsinchu TW | ||