| 发明名称 | Cell transdifferentiation into brown adipocytes | ||
| 摘要 | A method for converting animal cells into brown adipose tissue cells is provided that includes transforming the animal cells using an expression vector. The expression vector includes a nucleotide sequence encoding HB-EGF operatively linked to a promoter and a nucleotide sequence encoding ADAM 12 operatively linked to a promoter. Converting animal cells to brown adipose tissue cells can be used to treat obesity or to treat cancer by converting target cells to brown adipose tissue cells. | ||
| 申请公布号 | US8835112(B2) | 申请公布日期 | 2014.09.16 |
| 申请号 | US201313898293 | 申请日期 | 2013.05.20 |
| 申请人 | Miami University | 发明人 | Harding Paul Anthony;Zhou Zhenqing |
| 分类号 | C12Q1/68;C07H21/02;A61K48/00;C12N15/85;C12N15/86 | 主分类号 | C12Q1/68 |
| 代理机构 | Calfee Halter & Griswold LLP | 代理人 | Calfee Halter & Griswold LLP |
| 主权项 | 1. A method for converting animal cells into brown adipose tissue cells, comprising transforming the animal cells using an expression vector comprising a nucleotide sequence encoding HB-EGF operatively linked to a promoter and a nucleotide sequence encoding ADAM 12 operatively linked to a promoter; wherein the animal cells are converted in vitro. | ||
| 地址 | Oxford OH US | ||