| 发明名称 | Macromolecular diffusion and release from self-assembled β-hairpin peptide hydrogels | ||
| 摘要 | A hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33 in an aqueous medium at a pH of 7.4; wherein the anionic macromolecule has an isoelectric point of at most 6.8; and wherein the hydrogel is capable of retaining at least 25% of the anionic macromolecule after 28-day extraction at 37° C. with a pH=7.4 BTP buffer containing 150 mM NaCl. | ||
| 申请公布号 | US8834926(B2) | 申请公布日期 | 2014.09.16 |
| 申请号 | US200912533708 | 申请日期 | 2009.07.31 |
| 申请人 | University of Delaware | 发明人 | Schneidér Joel P.;Branco Monica C.;Pochan Darrin J.;Wagner Norman J. |
| 分类号 | A61K9/06;A61K38/10;A61K38/16;A61K9/00;A61K47/36 | 主分类号 | A61K9/06 |
| 代理机构 | RatnerPrestia | 代理人 | RatnerPrestia |
| 主权项 | 1. A hydrogel for delayed release of an anionic macromolecule, comprising the anionic macromolecule and a peptide in an aqueous medium at a pH of 7.4, wherein the anionic macromolecule has an isoelectric point of at most 6.8, wherein the anionic macromolecule is an anionic protein, wherein the peptide is selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33, and wherein peptide is present in an amount effective to retain at least 25% of the anionic macromolecule after 28-day extraction of the hydrogel at 37° C. with a pH=7.4 BTP buffer containing 150 mM NaCl. | ||
| 地址 | Newark DE US | ||