| 摘要 |
The present invention provides lipid emulsions and methods of intravenously administering lipid emulsions to treat systemic toxicity caused by foreign lipophilic and amphiphilic substances. In particular, methods are provided to treat cardiovascular impairment, such as cardiotoxicity, asystole and ischemia of the brain and heart, and neurological impairments, such as seizures and comas, caused by foreign lipophilic and amphiphilic substances, including cardiovascular impairment caused by local anesthetics, tricyclic antidepressants, sodium channel blockers, and calcium channel blockers. |
| 主权项 |
1. A method of treating cardiovascular impairment in a patient caused by one or more foreign substances already administered to or ingested by the patient, said method comprising:
intravenously administering a lipid emulsion composition to the patient wherein said lipid emulsion comprises between about 10 and about 40 percent oil by weight, about 1 to about 5 percent emulsifier by weight, about 1 to about 5 percent tonicity modifier by weight, and about 58 to about 88 percent water by weight, wherein said one or more foreign substances are lipophilic or amphiphilic substances able to be absorbed by the lipid emulsion composition in the patient's bloodstream, and wherein said one or more foreign substances are selected from the group consisting of bupivacaine, lidocaine, mepivacaine, etidocaine, amethocaine, tetracaine, procaine, 2-chloroprocaine, cocaine, prilocaine, procainamide, levobupivacaine, ropivacaine, dibucaine, and combinations thereof. |
