Medical implants and methods of making medical implants

摘要

A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

主权项

1. A medical implant device comprising:
a device substrate having a surface; a silane derivative coating comprising a terminal amine, wherein the silane derivative coating is covalently bonded to the surface; a bioactive agent; and a hetero-bifunctional polyethylene glycol spacer comprising a carboxyl group and an amine group; wherein the spacer is between the silane derivative coating and the bioactive agent, the carboxyl group of the polyethylene glycol spacer being covalently bonded to the terminal amine of the silane derivative coating through a peptide bond and the amine group of the polyethylene glycol spacer being covalently bonded to the bioactive agent through a peptide bond; wherein the silane derivative coating is first bonded to the surface before bonding to the polyethylene glycol spacer.