| 摘要 |
The present invention relates to a ribo nucleic acid (RNA) aptamer binding to IL-8 and to a use thereof. Specifically, an aptamer particularly binding to IL-8 is selected from an RNA library by using systematic evolution of ligands by exponential enrichment (SELEX) and the movement and intracellular signal transduction of IL-8-induced neutrophil and the invasion of cancer cells are inhibited by the aptamer binds to IL-8 with high binding affinity and checked. Also, a truncated form of the aptamer was produced, and it was confirmed that the truncated form of the aptamer binds to IL-8, with high binding affinity, and thus inhibits the movement and intracellular signal transduction of IL-8-induced neutrophil, and Ca^2+ mobilization. Therefore, it was confirmed that the aptamer binding to IL-8 in the present invention can be effectively used for preventing and treating cancer or inflammatory diseases. |
