| 摘要 |
<p>An Ivacaftor preparation method and intermediate thereof, the method forms a quinoline ring by condensing the compound of formula III under an alkaline condition, or conducting reduction and cyclization reactions for the compound of formula VI under a reduction condition, thus avoiding the high-temperature condition required for forming the quinoline ring. The method has a high yield, low cost, and mild reaction condition, etc.</p> |
| 申请人 |
TOPHARMAN SHANGHAI CO., LTD.;SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;TOPHARMAN SHANDONG CO., LTD. |
发明人 |
LI, JIANFENG;MA, WENPENG;JIANG, XIANGRUI;ZHANG, RONGXIA;ZHU, FUQIANG;CHEN, WEIMING;ZHAO, XIANGUO;SHEN, JINGSHAN |
