HUMAN ANTIBODIES TO SERUM RESISTANCE-ASSOCIATED PROTEIN FROM TRYPANOSOMA BRUCEI RHODESIENSE

摘要

The present invention provides antibodies that bind to serum resistance-associated (SRA) protein of Trypanosoma brucei rhodesiense, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to SRA. The antibodies of the invention are useful for inhibiting or neutralizing SRA activity, thus providing a means of treating human African trypanosomiasis (sleeping sickness), and symptoms associated with the disease. The antibodies of the invention may also be useful for diagnosis of sleeping sickness.