发明名称 CRYSTALLINE FORM HAVING SPECIFIC CRYSTAL HABIT AND PHARMACEUTICAL COMPOSITION|CONTAINING THIS CRYSTALLINE FORM AS ACTIVE INGREDIENT
摘要 Means for improving the solubility of luliconazole is provided. A crystal of luliconazole represented by the following formula is provided, wherein the crystal has such a crystal habit that (011) plane is a specific crystal growth plane. The crystal is characterized in that I(011) with respect to a sum total of I(001), I(100), I(10-1), I(011), I(110), I(11-1), I(10-2), I(11-2), I(020), I(021), I(20-2), I(121), I(013), I(11-3), and I(221) is not less than 25%, provided that integrated intensities of diffraction peaks, which correspond to the (001), (100), (10-1), (011), (110), (11-1), (10-2), (11-2), (020), (021), (20-2), (121), (013), (11-3), and (221) planes, are designated as I(001), I(100), I(10-1), I(011), I(110), I(11-1), I(10-2), I(11-2), I(020), I(021), I(20-2), I(121), I(013), I(11-3), and I(221) respectively in relation to the diffraction peaks detected in a range of 2&thetas;= 5 to 35° in a powder X-ray diffractometry using CuKα radiation.
申请公布号 WO2014136282(A1) 申请公布日期 2014.09.12
申请号 WO2013JP67952 申请日期 2013.06.24
申请人 POLA PHARMA INC.;NIHON NOHYAKU CO., LTD. 发明人 MASUDA, TAKAAKI;MIYATA, YOSHIYUKI;KANEDA, HIDEO
分类号 C07D409/06;A61K31/4178;A61P31/10 主分类号 C07D409/06
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