EX VIVO PRODUCTION OF PLATELETS FROM HEMATOPOIETIC STEM CELLS AND THE PRODUCT THEREOF

摘要

The present invention relates to a method of producing platelets (characterized by CD41+ and CD42+) from hematopoietic stem cells ex vivo. The invention further relates to a composition comprising the ex vivo produced platelets and a reagent comprising an aryl hydrocarbon antagonist and its use in autologous or allogeneic transfusion for the treatment of thrombocytopenia, thereby treating disease and conditions that caused the thrombocytopenia.