发明名称 |
METHOD AND SYSTEM FOR DETERMINING A BIOLOGICAL RESPONSE OF A TARGET TO A SOLUBLE CANDIDATE SUBSTANCE |
摘要 |
<p>A method for determining a biological response of a target (41, 42) to a soluble candidate substance comprises the steps: introducing a soluble candidate substance into a laminar flow of a buffer liquid (2) to form a candidate substance solute (3) having an initial concentration profile (31); dispersing the initial concentration profile (31) to form a dispersed concentration profile (32); directing the dispersed concentration profile (32) into a detection channel (12) to form a final symmetrical concentration profile (33) therein; introducing a target into the detection channel (12) to obtain a combined concentration profile comprising a constant target concentration profile overlying the final symmetrical concentration profile (33); holding in the detection channel (12) at least one half of the combined concentration profile; and optically scanning the combined concentration profile to detect an optical signal representative of the biological response of the target to the soluble candidate substance.</p> |
申请公布号 |
CA2902786(A1) |
申请公布日期 |
2014.09.12 |
申请号 |
CA20142902786 |
申请日期 |
2014.03.04 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
WERNER, MICHAEL;MARTIN, RAINER E.;HOCHSTRASSER, REMO |
分类号 |
G01N33/536;B01L3/00;G01N33/558 |
主分类号 |
G01N33/536 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|