| 摘要 |
The present invention relates to an RNA aptamer binding to IL-8 and a use thereof. More particularly, an aptamer specifically binding to IL-8 was selected from an RNA library by using SELEX, and it was confirmed that the aptamer binds to IL-8, with high binding affinity, and thereby inhibits the movement and intracellular signal transduction of IL-8-induced neutrophil and the invasion of cancer cells. Also, a truncated form of the aptamer was produced, and it was confirmed that the truncated form of the aptamer binds to IL-8, with high binding affinity, and thereby inhibits the movement and intracellular signal transduction of IL-8-induced neutrophil, and Ca2+ mobilization. Therefore, it was confirmed that the aptamer binding to IL-8 in the present invention can be effectively used for preventing and treating cancer or inflammatory diseases. |
