Amphotericin Analogous Compounds and Pharmaceutical Compositions Containing Them

摘要

The present invention relates to polyene macrolide derivatives according to the formula:;;wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.

主权项

1. Polyene macrolide derivatives according to formula (A): or a pharmaceutically acceptable salt thereof, wherein M is a macrocyclic lactone ring; N is polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroarylalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or that the character of zwitterions is restored.