Biotin-Decorated Fluorescent Silica Nanoparticles With Aggregation-Induced Emission for Tumor Cell Targeting and Long-Term Tumor Cell Tracking

摘要

Fluorescent silica nanoparticles with aggregation induced emission characteristics as well as methods for attaching biotin thereto for tumor cell targeting and long-term cell tracking. Additionally, dendrimers decorated with AIR fluorogens.

主权项

1. A fluorescent silica nanoparticle (FSNP) with aggregation induced emission characteristics comprising a backbone structure selected from the group consisting of:wherein
R1 is selected from the group consisting of H, alkyl, unsaturated alkyl, aryl, vinyl, acetyl, heteteroalkyl, cycloalkyl, heterocycloalkyl, and heteroaryl; X is (R2)nY(CH2)mSi(OC2H5)p; n, m, and p are each independently 0 to 20; Y is NH, O, S, or any other chalcogen; and each R2 is independently selected from the group consisting of a direct bond, alkyl, alkoxy, unsaturated alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and combinations thereof; and wherein the fluorescent silica nanoparticles are modified with biotin molecules on the nanoparticle surface.