SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF

摘要

Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.

主权项

1. A compound comprising a saccharide moiety and a non-hydrophobic linker being attached thereto, said linker comprising a poly(alkylene glycol) chain of at least 18 atoms in length, said poly(alkylene glycol) comprising 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 alkylene glycol units.