HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR

摘要

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

主权项

1. An isolated nucleic acid molecule encoding an antibody or antibody fragment which specifically binds human interleukin-6 receptor (hIL-6R), wherein the antibody or antibody fragment comprises three heavy chain complementarity determining region (CDR) sequences and three light chain CDR sequences, wherein the three heavy chain CDR sequences comprise a combination selected from the group consisting of SEQ ID NO:149, 151 and 153; SEQ ID NO:5, 7 and 9; and SEQ ID NO:181, 183 and 185; and wherein the three light chain CDR sequences comprise a combination selected from the group consisting of SEQ ID NO:157, 159 and 161; SEQ ID N0:13, 15 and 17; and SEQ ID NO:189, 191 and 193.