发明名称 CEPHEM DERIVATIVE HAVING CATECHOL GROUP
摘要 A compound represented by formula (I) or a pharmaceutically acceptable salt thereof wherein A represents a group represented by one of formulae (i)-(iii); B represents a group represented by formula (v) or (vi); and E represents a substituted or unsubstituted heterocyclic group having a cationic nitrogen atom.;
申请公布号 US2014256697(A1) 申请公布日期 2014.09.11
申请号 US201214349227 申请日期 2012.10.03
申请人 SHIONOGI & CO., LTD. 发明人 Yamawaki Kenji;Sano Masayuki;Sato Jun
分类号 C07D501/56 主分类号 C07D501/56
代理机构 代理人
主权项 1. A compound of formula (I): wherein, A is a group of any one of the following formula (i) to (iii): wherein, m and k are each independently an integer of 0 to 3; Z is —C(═O)—N(—R5)—, —N(—R5)—C(═O)—, —S(═O)2—N(—R5)—, or —N(—R5)—S(═O)2—; R1 is each independently hydrogen atom, alkyl, carboxy, or haloalkyl; R2 is each independently hydrogen atom, alkyl, carboxy, or haloalkyl; R3 is each independently hydrogen atom, alkyl, or haloalkyl; R4 is each independently hydrogen atom, alkyl, or haloalkyl; R1 and R2, and R3 and R4 taken together with a neighboring atom may form substituted or unsubstituted carbocyclic group, or substituted or unsubstituted heterocyclic group; R5 is hydrogen atom, or alkyl; RA and RB are each independently hydrogen atom, halogen atom, hydroxyl, carboxyl, alkyl, or haloalkyl; B is a group of the following formula (v) or (vi): wherein, X is —CH═, —C(—Cl)═, or —N═; RC and RD are each independently hydrogen atom, halogen atom, hydroxyl, amino, alkyl, or haloalkyl; E is a substituted or unsubstituted heterocyclic group having a cationic nitrogen atom, provided that when A is formula (iii), B is formula (vi), or a pharmaceutically acceptable salt thereof.
地址 Osaka-shi, Osaka JP