| 发明名称 |
ANTIBIOTIC CONJUGATES WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS |
| 摘要 |
The present invention describes single drug entities, formed by connecting an antibiotic moiety via a linker with a non-steroidal anti-inflammatory drug (NSAID) moiety. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual antibiotic and NSAID drug. |
| 申请公布号 |
US2014256666(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201414198881 |
申请日期 |
2014.03.06 |
| 申请人 |
Allergan, Inc. |
发明人 |
Sinha Santosh C.;Bhat Smita S.;Chow Ken;WANG LIMING;GARST MICHAEL E.;ATTAR MAYSSA;SWIFT BRANDON D. |
| 分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A hybrid compound comprising an antibiotic moiety and a nonsteroidal anti-inflammatory drug moiety, or a pharmaceutical salt thereof, which are connected via two separate covalent bonds to a linker such that said covalent bonds degrade in vivo to yield the antibiotic and the nonsteroidal anti-inflammatory drug. |
| 地址 |
Irvine CA US |
