| 发明名称 |
Steroid conjugates |
| 摘要 |
The present invention describes steroid conjugates. These single drug entities are formed by connecting two or more steroids via a linker. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual steroid drugs. |
| 申请公布号 |
US2014256696(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201414199514 |
申请日期 |
2014.03.06 |
| 申请人 |
Allergan, Inc. |
发明人 |
Sinha Santosh C.;Chow Ken;WANG LIMING;GARST MICHAEL E.;ATTAR MAYSSA;SWIFT BRANDON D. |
| 分类号 |
A61K47/48;A61K9/00 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A hybrid compound comprising two steroid moieties, or a pharmaceutical salt thereof, which are connected via two covalent bonds to a linker such that said compound degrades in vivo to yield the two steroids, wherein each bond is an ester bond. |
| 地址 |
Irvine CA US |
