METHODS OF BLOCKING CANCER STEM CELL GROWTH

摘要

Disclosed herein are antibodies against GPR49 and uses of such antibodies. The antibodies can be monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies, and methods of blocking cancer stem cell growth with such antibodies.

主权项

1. A method of blocking cancer stem cell growth, comprising administering an effective amount of a monoclonal antibody that binds to G-Protein Coupled Receptor 49 (GPR49) polypeptide with a Kd of less than 10×10−9 M to a cancer stem cell, wherein the GPR49 polypeptide comprises the amino acid sequence of SEQ ID NO: 1 and the effective amount is sufficient block cancer stem cell growth.