| 发明名称 |
METHODS OF MONITORING AND ANALYZING METABOLIC ACTIVITY PROFILES DIAGNOSTIC AND THERAPEUTIC USES OF SAME |
| 摘要 |
A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of:;(i) non-volatile soluble metabolic products;
(ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and
(iii) volatile soluble metabolic products;
wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay. |
| 申请公布号 |
US2014255972(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201414280612 |
申请日期 |
2014.05.18 |
| 申请人 |
Ramot at Tel-Aviv University Ltd. |
发明人 |
TIROSH Reuven;Patolsky Fernando;Peretz-Soroka Hagit |
| 分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of measuring a metabolic activity (MA) of a non-pathogenic immune cell, the method comprising independently measuring in an extracellular environment of the non-pathogenic immune cell, time-dependent acidification profiles due to secretion of:
(i) non-volatile soluble metabolic products and volatile soluble metabolic products; (ii) non-volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein said measuring acidification profile of said (ii) is effected in an air-exposed chamber, and wherein said measuring acidification profile of said (i) is effected in an air-sealed chamber, and wherein said measuring acidification profile of said (iii) is by subtracting an acidification profile of said (ii) from an acidification profile of said (i), and further wherein at least one of said time dependent acidification profiles is indicative of the metabolic activity of the non-pathogenic immune cell. |
| 地址 |
Tel-Aviv IL |
