发明名称 |
Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells |
摘要 |
Compositions and methods for enhancing an immune response with an adjuvant composition comprising: an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to at least a portion of a TLR agonist; and a pharmaceutically acceptable carrier are disclosed herein. The conjugate and agonist are each comprised in an amount such that, in combination with the other, are effective to produce the immune response in a human or animal subject in need of immunostimulation. |
申请公布号 |
AU2011289234(B2) |
申请公布日期 |
2014.09.11 |
申请号 |
AU20110289234 |
申请日期 |
2011.08.12 |
申请人 |
BAYLOR RESEARCH INSTITUTE |
发明人 |
ZURAWSKI, GERARD;BANCHEREAU, JACQUES F.;FLAMAR, ANNE-LAURE |
分类号 |
A61K39/39;A61K39/00;A61K39/02;A61K39/106;A61K39/112;A61K39/12;A61K39/395 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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